1ucf
From Proteopedia
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The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease
Contents |
Overview
DJ-1 is a multifunctional protein that plays essential roles in tissues, with higher order biological functions such as the testis and brain. DJ-1, is related to male fertility, and its level in sperm decreases in response, to exposure to sperm toxicants. DJ-1 has also been identified as a, hydroperoxide-responsive protein. Recently, a mutation of DJ-1 was found, to be responsible for familial Parkinson's disease. Here, we present the, crystal structure of DJ-1 refined to 1.95-A resolution. DJ-1 forms a dimer, in the crystal, and the monomer takes a flavodoxin-like Rossmann-fold., DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii, and, belongs to the Class I glutamine amidotransferase-like superfamily., However, DJ-1 contains an additional alpha-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1 and appears to regulate, the enzymatic activity. DJ-1 may induce conformational changes to acquire, catalytic activity in response to oxidative stress.
Disease
Known diseases associated with this structure: Amyotrophic lateral sclerosis-Parkinsonism/dementia complex 2 OMIM:[602533], Parkinson disease 7, autosomal recessive early-onset OMIM:[602533]
About this Structure
1UCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease., Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F, J Biol Chem. 2003 Aug 15;278(33):31380-4. Epub 2003 Jun 8. PMID:12796482
Page seeded by OCA on Mon Nov 12 19:33:17 2007
