1uun
From Proteopedia
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MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)
Overview
Mycobacteria have low-permeability outer membranes that render them, resistant to most antibiotics. Hydrophilic nutrients can enter by way of, transmembrane-channel proteins called porins. An x-ray analysis of the, main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric, goblet-like conformation with a single central channel. This is the first, structure of a mycobacterial outer-membrane protein. No structure-related, protein was found in the Protein Data Bank. MspA contains two consecutive, beta barrels with nonpolar outer surfaces that form a ribbon around the, porin, which is too narrow to fit the thickness of the mycobacterial outer, membrane in contemporary models.
About this Structure
1UUN is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.
Reference
The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314
Page seeded by OCA on Sun Nov 25 04:24:39 2007
