2b7a

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Template:STRUCTURE 2b7a

Contents 1 The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor 2 Disease 3 About this Structure 4 Reference

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Template:ABSTRACT PUBMED 16174768

Disease

Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]

About this Structure

2B7A is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ, Treutlein H, Wilks AF, Rossjohn J. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood. 2006 Jan 1;107(1):176-83. Epub 2005 Sep 20. PMID:16174768 doi:http://dx.doi.org/10.1182/blood-2005-06-2413

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