1uzg

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spinqualitylabelsall models 1uzg, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN

Overview

Dengue virus is an emerging global health threat. The major envelope, glycoprotein, E, mediates viral attachment and entry by membrane fusion., Antibodies that bind but fail to neutralize noncognate serotypes enhance, infection. We have determined the crystal structure of a soluble fragment, of the envelope glycoprotein E from dengue virus type 3. The structure, closely resembles those of E proteins from dengue type 2 and tick-borne, encephalitis viruses. Serotype-specific neutralization escape mutants in, dengue virus E proteins are all located on a surface of domain III, which, has been implicated in receptor binding. While antibodies against epitopes, in domain I are nonneutralizing in dengue virus, there are neutralizing, antibodies that recognize serotype-conserved epitopes in domain II. The, mechanism of neutralization for these antibodies is probably inhibition of, membrane fusion. Our structure shows that neighboring glycans on the viral, surface are spaced widely enough (at least 32 A) that they can interact, with multiple carbohydrate recognition domains on oligomeric lectins such, as DC-SIGN, ensuring maximum affinity for these putative receptors.

About this Structure

1UZG is a Single protein structure of sequence from Dengue virus type 1 with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:15613349

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