2gs2

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Template:STRUCTURE 2gs2

Contents 1 Crystal Structure of the active EGFR kinase domain 2 Disease 3 About this Structure 4 Reference

Crystal Structure of the active EGFR kinase domain

Template:ABSTRACT PUBMED 16777603

Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

2GS2 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell. 2006 Jun 16;125(6):1137-49. PMID:16777603 doi:10.1016/j.cell.2006.05.013

Page seeded by OCA on Tue Feb 17 20:55:07 2009