2f7z
From Proteopedia
Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
Template:ABSTRACT PUBMED 16413780
About this Structure
2F7Z is a 2 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Des Jong R, Oltersdorf T, Stoll VS, Jakob CG, Rosenberg SH, Giranda VL. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7. Epub 2006 Jan 18. PMID:16413780 doi:10.1016/j.bmcl.2005.12.065
Page seeded by OCA on Tue Feb 17 09:13:54 2009
Categories: Bos taurus | Non-specific serine/threonine protein kinase | Abrams, J. | Dinges, J. | Fisher, J. | Giranda, V L. | Gong, J. | Jakob, C G. | Johnson, E F. | Jong, R Des. | Klinghofer, V. | Li, Q. | Li, T. | Liu, X. | Luo, Y. | Oltersdorf, T. | Packard, G. | Rosenberg, S H. | Shi, Y. | Song, X. | Stoll, V S. | Thomas, S. | Woods, K W. | Zhu, G D. | Akt inhibitor | Protein kinase some