1xp9

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spinqualitylabelsall models 1xp9, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side, chains or alkylated linkers was prepared. Minor modifications in the side, chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

Disease

Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[133430], Breast cancer OMIM:[133430], Estrogen resistance OMIM:[133430], HDL response to hormone replacement, augmented OMIM:[133430], Migraine, susceptibility to OMIM:[133430], Myocardial infarction, susceptibility to OMIM:[133430]

About this Structure

1XP9 is a Single protein structure of sequence from Homo sapiens with AIJ as ligand. Full crystallographic information is available from OCA.

Reference

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers., Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML, Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. PMID:15582421

Page seeded by OCA on Mon Nov 12 20:09:10 2007