1xwd
From Proteopedia
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Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor
Contents |
Overview
Follicle-stimulating hormone (FSH) is central to reproduction in mammals., It acts through a G-protein-coupled receptor on the surface of target, cells to stimulate testicular and ovarian functions. We present here the, 2.9-A-resolution structure of a partially deglycosylated complex of human, FSH bound to the extracellular hormone-binding domain of its receptor, (FSHR(HB)). The hormone is bound in a hand-clasp fashion to an elongated, curved receptor. The buried interface of the complex is large (2,600 A2), and has a high charge density. Our analysis suggests that all glycoprotein, hormones bind to their receptors in this mode and that binding specificity, is mediated by key interaction sites involving both the common alpha- and, hormone-specific beta-subunits. On binding, FSH undergoes a concerted, conformational change that affects protruding loops implicated in receptor, activation. The FSH-FSHR(HB) complexes form dimers in the crystal and at, high concentrations in solution. Such dimers may participate in, transmembrane signal transduction.
Disease
Known diseases associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[136530], Ovarian dysgenesis 1 OMIM:[136435], Ovarian hyperstimulation syndrome OMIM:[136435], Ovarian response to FSH stimulation OMIM:[136435], Ovarian sex cord tumors OMIM:[136435]
About this Structure
1XWD is a Protein complex structure of sequences from Homo sapiens with NAG and SO4 as ligands. Full crystallographic information is available from OCA.
Reference
Structure of human follicle-stimulating hormone in complex with its receptor., Fan QR, Hendrickson WA, Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415
Page seeded by OCA on Mon Nov 12 20:11:43 2007
