2vki

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Image:2vki.png

Template:STRUCTURE 2vki

STRUCTURE OF THE PDK1 PH DOMAIN K465E MUTANT

Template:ABSTRACT PUBMED 18347057

About this Structure

2VKI is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bayascas JR, Wullschleger S, Sakamoto K, Garcia-Martinez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol. 2008 May;28(10):3258-72. Epub 2008 Mar 17. PMID:18347057 doi:10.1128/MCB.02032-07

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