1yjd
From Proteopedia
|
Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)
Overview
Naive T cell activation requires signaling by the T cell receptor and by, nonclonotypic cell surface receptors. The most important costimulatory, protein is the monovalent homodimer CD28, which interacts with CD80 and, CD86 expressed on antigen-presenting cells. Here we present the crystal, structure of a soluble form of CD28 in complex with the Fab fragment of a, mitogenic antibody. Structural comparisons redefine the evolutionary, relationships of CD28-related proteins, antigen receptors and adhesion, molecules and account for the distinct ligand-binding and stoichiometric, properties of CD28 and the related, inhibitory homodimer CTLA-4., Cryo-electron microscopy-based comparisons of complexes of CD28 with, mitogenic and nonmitogenic antibodies place new constraints on models of, antibody-induced receptor triggering. This work completes the initial, structural characterization of the CD28-CTLA-4-CD80-CD86 signaling system.
About this Structure
1YJD is a Single protein structure of sequence from Homo sapiens and Mus musculus with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a soluble CD28-Fab complex., Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, Fennelly JA, Vowles C, Hanke T, Walse B, Hunig T, Sorensen P, Stuart DI, Davis SJ, Nat Immunol. 2005 Mar;6(3):271-9. Epub 2005 Feb 6. PMID:15696168
Page seeded by OCA on Mon Nov 12 20:20:48 2007
