1ysv
From Proteopedia
|
Solution structure of the central region of the human GluR-B R/G pre-mRNA
Overview
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific, conversion of adenosine to inosine in primary mRNA transcripts, thereby, affecting coding potential of mature mRNAs. Structural determinants that, define the adenosine moieties for specific ADARs-mediated deaminations are, currently unknown. We report the solution structure of the central region, of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding, the subunit B of the glutamate receptor (R/G site). The structure reveals, that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts, a novel fold. The fold is stabilized by a complex interplay of hydrogen, bonds and stacking interactions. We propose that this new pentaloop, structure is an important determinant of the R/G site recognition by, ADAR2.
About this Structure
1YSV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813
Page seeded by OCA on Sun Nov 25 04:33:27 2007
Categories: Protein complex | Allain, F.H. | Stefl, R. | Adar2 | Nmr | Pentaloop | Rna | Rna editing | Stem-loop | Structure
