1go9

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Image:1go9.png

Template:STRUCTURE 1go9

MONITORING THE STRUCTURAL CONSEQUENCES OF PHE12-->D-PHE12 AND LEU15-->AIB15 SUBSTITUTION IN H/R CORTICOTROPIN RELEASING HORMONE: IMPLICATIONS FOR DESIGN OF CRH ANTAGONISTS.

Template:ABSTRACT PUBMED 12473096

About this Structure

1go9 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Spyroulias GA, Papazacharias S, Pairas G, Cordopatis P. Monitoring the structural consequences of Phe12-->D-Phe and Leu15-->Aib substitution in human/rat corticotropin releasing hormone. Implications for design of CRH antagonists. Eur J Biochem. 2002 Dec;269(24):6009-19. PMID:12473096
  • Romier C, Bernassau JM, Cambillau C, Darbon H. Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. Protein Eng. 1993 Feb;6(2):149-56. PMID:8386360

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