1tmm
From Proteopedia
Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin
Template:ABSTRACT PUBMED 15952765
About this Structure
1tmm is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Li Y, Blaszczyk J, Wu Y, Shi G, Ji X, Yan H. Is the critical role of loop 3 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase in catalysis due to loop-3 residues arginine-84 and tryptophan-89? Site-directed mutagenesis, biochemical, and crystallographic studies. Biochemistry. 2005 Jun 21;44(24):8590-9. PMID:15952765 doi:10.1021/bi0503495
- Xiao B, Shi G, Chen X, Yan H, Ji X. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Structure. 1999 May;7(5):489-96. PMID:10378268
- Blaszczyk J, Shi G, Yan H, Ji X. Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution. Structure. 2000 Oct 15;8(10):1049-58. PMID:11080626
- Shi G, Blaszczyk J, Ji X, Yan H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. PMID:11311059
Categories: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | Escherichia coli | Blaszczyk, J. | Ji, X. | Li, Y. | Shi, G. | Wu, Y. | Yan, H. | 6-hydroxymethyl-7 | 6-hydroxymethylpterin | 8-dihydropterin | Antimicrobial agent | Catalytic mechanism | Drug design | Folate | Hppk | Product release | Pterin | Pyrophosphokinase | Pyrophosphoryl transfer | Substrate specificity | Ternary complex | Transferase | X-ray crystallography
