1zig
From Proteopedia
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GAGA RNA TETRALOOP, NMR, 10 STRUCTURES
Overview
RNA hairpin loops containing a GNRA consensus sequence are the most, frequently occurring hairpins in a variety of prokaryotic and eukaryotic, RNAs. These tetraloops play important functional roles in RNA folding, in, RNA-RNA tertiary interactions and as protein binding sites. Homo and, heteronuclear NMR spectroscopy have been used to determine the structures, of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA, and GAAA loops closed by a C-G base pair. Analysis of the structures of, these three hairpin loops reveals a network of heterogeneous hydrogen, bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond, and several 2' OH-base hydrogen bonds. These intramolecular interactions, and the extensive base stacking in the loop help explain the high, thermodynamic stability and give insight into the diverse biological roles, of the GNRA RNA hairpins.
About this Structure
1ZIG is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624
Page seeded by OCA on Sun Nov 25 04:53:45 2007
Categories: Protein complex | Heus, H.A. | Jucker, F.M. | Moors, E. | Pardi, A. | Yip, P.F. | Gnra | Hairpin | Ribonucleic acid | Rna | Tetraloops
