3faa

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Image:3faa.png

Template:STRUCTURE 3faa

Contents

Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor

Template:ABSTRACT PUBMED 19135364

Disease

Known disease associated with this structure: Loeys-Dietz syndrome, type 1A OMIM:[190181], Loeys-Dietz syndrome, type 2A OMIM:[190181]

About this Structure

3FAA is a 5 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bonafoux D, Chuaqui C, Boriack-Sjodin PA, Fitch C, Hankins G, Josiah S, Black C, Hetu G, Ling L, Lee WC. 2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg Med Chem Lett. 2009 Feb 1;19(3):912-6. Epub 2008 Dec 11. PMID:19135364 doi:10.1016/j.bmcl.2008.11.119

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