2a0t

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Image:2a0t.gif

2a0t

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NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1

Overview

Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.

About this Structure

2A0T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

Reference

FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:16231900

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