2a11

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spinqualitylabelsall models 2a11, resolution 2.100Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis

Overview

RNase III enzymes are a highly conserved family of proteins that, specifically cleave double-stranded (ds)RNA. These proteins are involved, in a diverse group of functions, including ribosomal RNA processing, mRNA, maturation and decay, snRNA and snoRNA processing, and RNA interference., Here we report the crystal structure of the nuclease domain of RNase III, from the pathogen Mycobacterium tuberculosis. Although globally similar to, other RNase III folds, this structure has some features not observed in, previously reported models. These include the presence of an additional, metal ion near the catalytic site, as well as conserved secondary, structural elements that are proposed to have functional roles in the, recognition of dsRNAs.

About this Structure

2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis with CA as ligand. Active as Ribonuclease III, with EC number 3.1.26.3 Full crystallographic information is available from OCA.

Reference

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207

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