2afr

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Image:2afr.gif

2afr, resolution 2.30Å

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The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

Overview

The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement, reaction of the cobalamin biosynthesis pathway. The protein has been, cloned and overexpressed as a His-tagged recombinant protein in, Escherichia coli. The crystal structures have been solved in two crystal, forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase, (CobH), an enzyme of the aerobic pathway to vitamin B12.

About this Structure

2AFR is a Single protein structure of sequence from Leptospira interrogans. Active as Precorrin-8X methylmutase, with EC number 5.4.1.2 Full crystallographic information is available from OCA.

Reference

The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313

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