2alv
From Proteopedia
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X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe, acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro), inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV), are described. These inhibitors exhibited antiviral activity against, SARS-CoV in infected cells in the micromolar range. An X-ray crystal, structure of our lead inhibitor (4) bound to SARS-3CLpro provided, important drug-design templates for the design of small-molecule, inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus with as ligand. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632
Page seeded by OCA on Tue Jan 29 18:04:35 2008
Categories: Human sars coronavirus | Single protein | Baker, S.C. | Fu, W. | Ghosh, A.K. | Harcourt, B.H. | Johnson, M.E. | Mesecar, A.D. | Ratia, K. | Rota, P.A. | Santarsiero, B.D. | Xi, K. | CY6 | 3c | 3cl | 3clpro | Anti-viral | Coronavirus | Inhibitor | Protease | Proteinase | Sars
