2aoz

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Image:2aoz.gif

2aoz, resolution 2.08Å

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Crystal structure of the myotoxin-II from Atropoides nummifer venom

Overview

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic, proteins which, although lacking catalytic activity, possess the ability, to disrupt biological membranes, inducing significant muscle-tissue loss, and permanent disability in severely envenomed patients. Since the, structural basis for their toxic activity is still only partially, understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue, from Atropoides nummifer, has been determined at 2.08 angstroms resolution, and the anion-binding site has been characterized.

About this Structure

2AOZ is a Single protein structure of sequence from Atropoides nummifer with SO4 as ligand. Full crystallographic information is available from OCA.

Reference

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766

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