1mfs
From Proteopedia
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DYNAMICAL BEHAVIOR OF THE HIV-1 NUCLEOCAPSID PROTEIN; NMR, 30 STRUCTURES
Overview
The HIV-1 nucleocapsid protein (NC) contains two CCHC-type zinc knuckle, domains that are essential for genome recognition, packaging and, infectivity. The solution structure of the protein has been determined, independently by three groups. Although the structures of the individual, zinc knuckle domains are similar, two of the studies indicated that the, knuckles behave as independently folded, non-interacting domains connected, by a flexible tether, whereas one study revealed the presence of, interknuckle NOE cross-peaks, which were interpreted in terms of a more, compact structure in which the knuckles are in close proximity. We have, collected multidimensional NMR data for the recombinant, isotopically, labeled HIV-1 NC protein, and confirmed the presence of weak interknuckle, NOEs. ... [(full description)]
About this Structure
1MFS is a [Single protein] structure of sequence from [Human immunodeficiency virus] with ZN as [ligand]. Structure known Active Site: MNG. Full crystallographic information is available from [OCA].
Reference
Dynamical behavior of the HIV-1 nucleocapsid protein., Lee BM, De Guzman RN, Turner BG, Tjandra N, Summers MF, J Mol Biol. 1998 Jun 12;279(3):633-49. PMID:9641983
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