2ax0
From Proteopedia
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Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)
Overview
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with, sub-micromolar biochemical potency have been identified which are, selective for the inhibition of HCV NS5b over other polymerases. The, structures of the complexes formed between several of these inhibitors and, HCV NS5b were determined by X-ray crystallography, and the inhibitors were, found to bind in an allosteric binding site separate from the active site., Structure-activity relationships and structural studies have identified, the mechanism of action for compounds in this series, several of which, possess drug-like properties, as unique, reversible, covalent inhibitors, of HCV NS5b.
About this Structure
2AX0 is a Single protein structure of sequence from Hepatitis c virus with SO4 and 5X as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
Reference
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:16451069
Page seeded by OCA on Wed Nov 21 08:25:43 2007
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Single protein | Anzola, J. | Chen, J.M. | Jaen, J.C. | Lee, G. | Li, Y. | Liu, J. | Mayorga, V. | Peterson, M.G. | Piper, D.E. | Powers, J.P. | Tonn, G.R. | Walker, N.P. | Wang, Z. | Ye, Q. | 5X | SO4 | Fingers | Hcv | Ns5b | Palm | Polymerase | Thumb
