2bzu
From Proteopedia
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HUMAN ADENOVIRUS SEROTYPE 41 FIBER HEAD
Overview
Human enteric adenoviruses of species F contain two fibers in the same, virion, a long fiber which binds to coxsackievirus and adenovirus receptor, (CAR) and a short fiber of unknown function. We have determined the, high-resolution crystal structure of the short fiber head of human, adenovirus serotype 41 (Ad41). The short fiber head has the characteristic, fold of other known fiber heads but has three unusual features. First, it, has much shorter loops between the beta-strands. Second, one of the, usually well-ordered beta-strands on the distal face of the fiber head is, highly disordered and this same region is sensitive to digestion with, pepsin, an enzyme occurring naturally in the intestinal tract, the, physiological environment of Ad41. Third, the AB loop has a deletion, giving it a distinct conformation incompatible with CAR binding.
About this Structure
2BZU is a Single protein structure of sequence from Human adenovirus 37. Full crystallographic information is available from OCA.
Reference
Crystal structure of enteric adenovirus serotype 41 short fiber head., Seiradake E, Cusack S, J Virol. 2005 Nov;79(22):14088-94. PMID:16254343
Page seeded by OCA on Wed Nov 21 08:58:15 2007
