2bip
From Proteopedia
Contents |
HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-R249S-N268D
Template:ABSTRACT PUBMED 15703170
About this Structure
2bip is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157
Categories: Homo sapiens | Fersht, A R. | Joerger, A C. | Activator | Anti-oncogene | Apoptosis | Disease mutation | Dna-binding | Dna-binding protein | Glycoprotein metal-binding | Li-fraumeni syndrome | Nuclear protein | P53 dna-binding domain | Phosphorylation | Second-site suppressor mutation | Superstable mutant | Transcription regulation | Transferase | Tumor suppressor
