2c5b

From Proteopedia

Revision as of 08:31, 3 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2c5b.jpg

2c5b, resolution 2.50Å

Drag the structure with the mouse to rotate

X-RAY CRYSTAL STRUCTURE OF 5'-FLUORODEOXYADENOSINE SYNTHASE FROM STREPTOMYCES CATTLEYA COMPLEXED WITH 2'DEOXY-5'DEOXY-FLUOROADENOSINE.

Overview

The fluorinase enzyme from Streptomyces cattleya displays an unusual, ability in biocatalysis in that it forms a C-F bond. We now report that, the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to, accommodate this substrate series. It emerges from this study that the, enzyme does not require a planar ribose conformation of the substrate to, catalyse C-F bond formation.

About this Structure

2C5B is a Single protein structure of sequence from Streptomyces cattleya with and as ligands. Active as Adenosyl-fluoride synthase, with EC number 2.5.1.63 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates., Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA, Org Biomol Chem. 2006 Apr 21;4(8):1458-60. Epub 2006 Mar 8. PMID:16604208

Page seeded by OCA on Sun Feb 3 10:31:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c5b"
Personal tools