1k7l

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spinqualitylabelsall models PDB ID 1k7l Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1k7l, resolution 2.50Å ()
Ligands:	,
Related:	1k74, 1fm6, 1fm9
Structural annotation: Resources: CATH : 1K7La00, 1K7Lc00, 1K7Le00, 1K7Lg00 UniProt : Q07869, Q66JL7
Functional annotation: Cellular component: nucleus Biological process: transcription regulation of transcription signal transduction regulation of transcription, DNA-dependent Molecular function: signal transducer activity transcription coactivator activity chromatin binding protein binding transcription regulator activity DNA binding nuclear hormone receptor binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide. 2 About this Structure 3 See Also 4 Reference

The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.

Template:ABSTRACT PUBMED 11698662

About this Structure

1k7l is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Peroxisome Proliferator-Activated Receptors

Reference

• Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:11698662 doi:10.1073/pnas.241410198
• Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7. PMID:11845213 doi:10.1038/415813a