3g04

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models PDB ID 3g04 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3g04, resolution 2.55Å ()
Ligands:	,
Gene:	TSHR (Homo sapiens)
Related:	1xwd
Structural annotation: Resources: InterPro : Ipr000276, Ipr017452, Ipr002274, Ipr002131
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody 2 About this Structure 3 See Also 4 Reference

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

Template:ABSTRACT PUBMED 17542669

About this Structure

3g04 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hormone
• Human Follicle-Stimulating Hormone Complexed with its Receptor

Reference

• Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid. 2007 May;17(5):395-410. PMID:17542669 doi:10.1089/thy.2007.0034
• Sanders J, Evans M, Premawardhana LD, Depraetere H, Jeffreys J, Richards T, Furmaniak J, Rees Smith B. Human monoclonal thyroid stimulating autoantibody. Lancet. 2003 Jul 12;362(9378):126-8. PMID:12867115
• Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Kiddie A, Brereton K, Premawardhana LD, Chirgadze DY, Nunez Miguel R, Blundell TL, Furmaniak J, Rees Smith B. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid. 2004 Aug;14(8):560-70. PMID:15320966 doi:10.1089/1050725041692918
• Nunez Miguel R, Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Blundell TL, Rees Smith B, Furmaniak J. Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling. Thyroid. 2004 Dec;14(12):991-1011. PMID:15650352 doi:10.1089/thy.2004.14.991
• Sanders J, Bolton J, Sanders P, Jeffreys J, Nakatake N, Richards T, Evans M, Kiddie A, Summerhayes S, Roberts E, Miguel RN, Furmaniak J, Smith BR. Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. Thyroid. 2006 Dec;16(12):1195-206. PMID:17199429 doi:10.1089/thy.2006.16.1195
• Sanders J, Miguel RN, Bolton J, Bhardwaja A, Sanders P, Nakatake N, Evans M, Furmaniak J, Smith BR. Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody. Thyroid. 2007 Aug;17(8):699-706. PMID:17725428 doi:10.1089/thy.2007.0041
• Nunez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. J Mol Endocrinol. 2008 Sep;41(3):145-64. Epub 2008 Jul 7. PMID:18606720 doi:10.1677/JME-08-0040