4djz

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Image:4djz.png

Template:STRUCTURE 4djz

Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold

Template:ABSTRACT PUBMED 22511776

About this Structure

4djz is a 6 chain structure with sequence from Homo sapiens and Schistocerca gregaria. Full crystallographic information is available from OCA.

Reference

  • Heja D, Harmat V, Fodor K, Wilmanns M, Dobo J, Kekesi KA, Zavodszky P, Gal P, Pal G. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease (MASP)-1 and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem. 2012 Apr 16. PMID:22511776 doi:10.1074/jbc.M112.354332

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OCA

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