3qkm

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Image:3qkm.png

Template:STRUCTURE 3qkm

Spirocyclic sulfonamides as AKT inhibitors

Template:ABSTRACT PUBMED 21420856

About this Structure

3qkm is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Xu R, Banka A, Blake JF, Mitchell IS, Wallace EM, Bencsik JR, Kallan NC, Spencer KL, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ. Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2335-40. Epub 2011 Feb 26. PMID:21420856 doi:10.1016/j.bmcl.2011.02.098

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