3bym

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Template:STRUCTURE 3bym

Contents 1 X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck 2 About this Structure 3 See Also 4 Reference

X-ray co-crystal structure aminobenzimidazole triazine 1 bound to Lck

Template:ABSTRACT PUBMED 18278858

About this Structure

3bym is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Proto-oncogene tyrosine-protein kinase
• Tyrosine kinase

Reference

• Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2008 Mar 27;51(6):1637-48. Epub 2008 Feb 16. PMID:18278858 doi:10.1021/jm701095m