4aqc

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Image:4aqc.png

Template:STRUCTURE 4aqc

Triazolopyridine-based Inhibitor of Janus Kinase 2

Template:ABSTRACT PUBMED 22594690

About this Structure

4aqc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dugan BJ, Gingrich DE, Mesaros EF, Milkiewicz KL, Curry MA, Zulli AL, Dobrzanski P, Serdikoff C, Jan M, Angeles TS, Albom MS, Mason JL, Aimone LD, Meyer SL, Huang Z, Wells-Knecht KJ, Ator MA, Ruggeri BA, Dorsey BD. A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779. J Med Chem. 2012 Jun 14;55(11):5243-54. Epub 2012 May 18. PMID:22594690 doi:10.1021/jm300248q

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