3lco

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Image:3lco.jpg

Template:STRUCTURE 3lco

Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R

Template:ABSTRACT PUBMED 20137931

About this Structure

3LCO is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Meyers MJ, Pelc M, Kamtekar S, Day J, Poda GI, Hall MK, Michener ML, Reitz BA, Mathis KJ, Pierce BS, Parikh MD, Mischke DA, Long SA, Parlow JJ, Anderson DR, Thorarensen A. Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1543-7. Epub 2010 Jan 21. PMID:20137931 doi:10.1016/j.bmcl.2010.01.078

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