3kgg

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Template:STRUCTURE 3kgg

Contents

X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): Perdeuteration of proteins for neutron diffraction

Template:ABSTRACT PUBMED 20383004

Function

[DFPA_LOLVU] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).[1]

About this Structure

3kgg is a 1 chain structure with sequence from Loligo vulgaris. Full crystallographic information is available from OCA.

Reference

  • Blum MM, Tomanicek SJ, John H, Hanson BL, Ruterjans H, Schoenborn BP, Langan P, Chen JC. X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): perdeuteration of proteins for neutron diffraction. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt, 4):379-85. Epub 2010 Mar 26. PMID:20383004 doi:10.1107/S1744309110004318
  1. ↑ Katsemi V, Lucke C, Koepke J, Lohr F, Maurer S, Fritzsch G, Ruterjans H. Mutational and structural studies of the diisopropylfluorophosphatase from Loligo vulgaris shed new light on the catalytic mechanism of the enzyme. Biochemistry. 2005 Jun 28;44(25):9022-33. PMID:15966726 doi:10.1021/bi0500675

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