3k5u
From Proteopedia
Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor
Template:ABSTRACT PUBMED 20039358
About this Structure
3k5u is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP. Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor. ChemMedChem. 2010 Feb 1;5(2):255-67. PMID:20039358 doi:10.1002/cmdc.200900339
- Coumar MS, Leou JS, Shukla P, Wu JS, Dixit AK, Lin WH, Chang CY, Lien TW, Tan UK, Chen CH, Hsu JT, Chao YS, Wu SY, Hsieh HP. Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. J Med Chem. 2009 Feb 26;52(4):1050-62. PMID:19140666 doi:10.1021/jm801270e
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Coumar, M S. | Hsieh, H P. | Leou, J S. | Wu, J S. | Wu, S Y. | Atp-binding site | Aurora kinase inhibitor | Cell cycle | Cytoskeleton | H-bonding | Kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Transferase | Virtual screening | X-ray co-crystal analysis
