3m3q

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Template:STRUCTURE 3m3q

Contents

Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide

Template:ABSTRACT PUBMED 20530247

Function

[ATLE_AGRAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.[1]

About this Structure

3m3q is a 2 chain structure with sequence from Agrocybe aegerita. Full crystallographic information is available from OCA.

Reference

  • Feng L, Sun H, Zhang Y, Li DF, Wang DC. Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. FASEB J. 2010 Oct;24(10):3861-8. Epub 2010 Jun 7. PMID:20530247 doi:10.1096/fj.10-159111
  1. ↑ Zhao C, Sun H, Tong X, Qi Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003 Sep 1;374(Pt 2):321-7. PMID:12757412 doi:10.1042/BJ20030300

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