4k00

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Template:STRUCTURE 4k00

Contents

Crystal structure of Slr0204, a 1,4-dihydroxy-2-naphthoyl-CoA thioesterase from Synechocystis

Function

[DNCH_SYNY3] Catalyzes the specific hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis. Is not active on benzoyl-CoA, phenylacetyl-CoA and aliphatic acyl-CoA thioesters.[1]

About this Structure

4k00 is a 2 chain structure with sequence from Synechocystis sp. pcc 6803 substr. kazusa. Full crystallographic information is available from OCA.

Reference

  1. ↑ Widhalm JR, van Oostende C, Furt F, Basset GJ. A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5599-603. doi:, 10.1073/pnas.0900738106. Epub 2009 Mar 25. PMID:19321747 doi:10.1073/pnas.0900738106

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