2esv

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spinqualitylabelsall models 2esv, resolution 2.600Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structure of the HLA-E-VMAPRTLIL/KK50.4 TCR complex

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

In contrast to antigen-specific immunity orchestrated by major, histocompatibility complex (MHC) class Ia molecules, the ancestrally, related nonclassical MHC class Ib molecules generally mediate innate, immune responses. Here we have demonstrated the structural basis by which, the MHC class Ib molecule HLA-E mediates an adaptive MHC-restricted, cytotoxic T lymphocyte response to human cytomegalovirus. Highly, constrained by host genetics, the response showed notable fine specificity, for position 8 of the viral peptide, which is the sole discriminator of, self versus nonself. Despite the evolutionary divergence of MHC class Ia, and class Ib molecules, the structure of the T cell receptor-MHC class Ib, complex was very similar to that of conventional T cell receptor-MHC class, Ia complexes. These results emphasize the evolutionary 'ambiguity' of, HLA-E, which not only interacts with innate immune receptors but also has, the functional capacity to mediate virus-specific cytotoxic T lymphocyte, responses during adaptive immunity.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2ESV is a Protein complex structure of sequences from Homo sapiens with IOD as ligand. Full crystallographic information is available from OCA.

Reference

Structural basis for a major histocompatibility complex class Ib-restricted T cell response., Hoare HL, Sullivan LC, Pietra G, Clements CS, Lee EJ, Ely LK, Beddoe T, Falco M, Kjer-Nielsen L, Reid HH, McCluskey J, Moretta L, Rossjohn J, Brooks AG, Nat Immunol. 2006 Mar;7(3):256-64. Epub 2006 Feb 12. PMID:16474394

Page seeded by OCA on Mon Nov 12 21:55:22 2007