3ncz

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Image:3ncz.jpg

Template:STRUCTURE 3ncz

X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor

Template:ABSTRACT PUBMED 20678931

About this Structure

3NCZ is a 4 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. Epub 2010 Aug 1. PMID:20678931 doi:10.1016/j.bmcl.2010.07.014

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