3nr5

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Template:STRUCTURE 3nr5

Contents

Crystal structure of human Maf1

Template:ABSTRACT PUBMED 20887893

Function

[MAF1_HUMAN] Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.[1] [2] [3]

About this Structure

3nr5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vannini A, Ringel R, Kusser AG, Berninghausen O, Kassavetis GA, Cramer P. Molecular basis of RNA polymerase III transcription repression by Maf1. Cell. 2010 Oct 1;143(1):59-70. PMID:20887893 doi:10.1016/j.cell.2010.09.002
  1. ↑ Shor B, Wu J, Shakey Q, Toral-Barza L, Shi C, Follettie M, Yu K. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem. 2010 May 14;285(20):15380-92. doi: 10.1074/jbc.M109.071639. Epub, 2010 Mar 16. PMID:20233713 doi:10.1074/jbc.M109.071639
  2. ↑ Michels AA, Robitaille AM, Buczynski-Ruchonnet D, Hodroj W, Reina JH, Hall MN, Hernandez N. mTORC1 directly phosphorylates and regulates human MAF1. Mol Cell Biol. 2010 Aug;30(15):3749-57. doi: 10.1128/MCB.00319-10. Epub 2010 Jun , 1. PMID:20516213 doi:10.1128/MCB.00319-10
  3. ↑ Kantidakis T, Ramsbottom BA, Birch JL, Dowding SN, White RJ. mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11823-8. doi:, 10.1073/pnas.1005188107. Epub 2010 Jun 11. PMID:20543138 doi:10.1073/pnas.1005188107

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