2f9b

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Image:2f9b.gif

2f9b, resolution 2.54Å

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Discovery of Novel Heterocyclic Factor VIIa Inhibitors

Contents

Overview

Structure-activity relationships and binding mode of novel heterocyclic, factor VIIa inhibitors will be described. In these inhibitors, a highly, basic 5-amidinoindole moiety has been successfully replaced with a less, basic 5-aminopyrrolo[3,2-b]pyridine scaffold.

Disease

Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2F9B is a Protein complex structure of sequences from Homo sapiens with N1H as ligand. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Full crystallographic information is available from OCA.

Reference

Discovery of novel heterocyclic factor VIIa inhibitors., Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB, Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. Epub 2006 Feb 3. PMID:16460932

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