Anaplastic lymphoma kinase

From Proteopedia

Revision as of 10:20, 28 April 2013 by Michal Harel (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:2xp2.png
Crystal Structure of human anaplastic lymphoma kinase complex with anti-cancer drug, 2xp2

Template:STRUCTURE 2xp2










Anaplastic lymphoma kinase (ALK) which is a tyrosine kinase receptor is active in the development of the brain. Chromosomal translocation is observed in ca. 60% anaplastic large-cell lymphomas. The translocation creates a fusion gene composed of the 3’ end of ALK and the 5’ end of nucleophosmin gene. EML4/ALK fusion gene is observed in ca. 4% of non-small-cell lung cancer. Aberrant ALK activity is observed in other carcinomas as well. ALK is comprised by an extracellular domain, a single pass transmembrane domain and an intracellular kinase domain.

3D Structures of anaplastic lymphoma kinase

Updated on 28-April-2013

ALK kinase domain

2xb7, 2xba, 3aox – hALK + inhibitor – human
3l9p, 2yhv, 2yjr, 2yjs, 4fnw, 4fnx, 4anl – hALK (mutant)
3lcs – hALK (mutant) + staurosporine
4dce, 4fob, 4foc, 4fod, 4fny, 4fnz – hALK (mutant) + inhibitor
3lct – hALK (mutant) + ADP
2xp2 – hALK + anti-cancer drug
2yfx, 4anq, 4ans – hALK (mutant) + anti-cancer drug

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Anaplastic_lymphoma_kinase"
Personal tools