Vitamin D receptor (VDR) is a transcription factor. Upon binding to vitamin D, VDR forms a heterodimer with retinoid-X receptor and binds to hormone response receptors on DNA causing gene expression. VDR contains a ligand binding domain (LBD) and hormone-binding domain.
3D structures of vitamin D receptor
1db1 – hVDR LBD + vitamin D – human
1txi, 2ham, 2har, 2has, 2hb7, 2hb8 - hVDR LBD + vitamin D analog
1rjk, 1rk3, 1rkg, 1rkh, 2o4j, 2o4r – rVDR LBD (mutant) + peroxisome proliferator-activated receptor peptide – rat
2zl9, 2zla, 2zlc - rVDR LBD + coactivator peptide DRIP + vitamin D analog
2zfx, 3a2h - rVDR LBD + coactivator peptide DRIP
3aun - rVDR LBD (mutsant) + coactivator peptide DRIP
2hbh - zVDR LBD + steroid receptor coactivator 1 peptide – zebrafish
2hc4 - zVDR LBD + steroid receptor coactivator 1 peptide + vitamin D
2hcd - zVDR LBD + steroid receptor coactivator 1 peptide
