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Contents 1 Bromodomain Structure 2 Role in the Nucleolar Remodeling Complex (NoRC) 3 BAZ2a Function 3.1 Role in Chromatin Remodeling 3.2 Medical Implications 4 References

Bromodomain Structure

spinqualitylabelsall models Structure of BAZ2b bromodomain (PDB entry 3g0l), BAZ2a similar Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Anything in this section will appear adjacent to the 3D structure and will be scrollable.

Role in the Nucleolar Remodeling Complex (NoRC)

BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues.

BAZ2a Function

Role in Chromatin Remodeling

As a critical member of the NoRC, BAZ2a in conjunction with SNF2H is responsible for modifying the compaction of chromatin, through The NoRC is also responsible for ribosomal DNA (rDNA) transcription silencing, by recruiting histone deacetylase (HDAC) and DNA methyltransferase (DNMT) to the rDNA promoter, effectively creating a region with the characteristics of heterochromatin and silencing rDNA transcription. ^[1]

Medical Implications

References

1. ↑ Santoro R, Li J, Grummt I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002 Nov;32(3):393-6. Epub 2002 Oct 7. PMID:12368916 doi:10.1038/ng1010