2go5
From Proteopedia
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Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex
Overview
Signal sequences of secretory and membrane proteins are recognized by the, signal recognition particle (SRP) as they emerge from the ribosome. This, results in their targeting to the membrane by docking with the SRP, receptor, which facilitates transfer of the ribosome to the translocon., Here, we present the 8 angstrom cryo-electron microscopy structure of a, "docking complex" consisting of a SRP-bound 80S ribosome and the SRP, receptor. Interaction of the SRP receptor with both SRP and the ribosome, rearranged the S domain of SRP such that a ribosomal binding site for the, translocon, the L23e/L35 site, became exposed, whereas Alu domain-mediated, elongation arrest persisted.
About this Structure
2GO5 is a Protein complex structure of sequences from Conyza sp., Homo sapiens, Mus musculus and Triticum sp.. Full crystallographic information is available from OCA.
Reference
Signal recognition particle receptor exposes the ribosomal translocon binding site., Halic M, Gartmann M, Schlenker O, Mielke T, Pool MR, Sinning I, Beckmann R, Science. 2006 May 5;312(5774):745-7. PMID:16675701
Page seeded by OCA on Mon Nov 12 22:20:20 2007
Categories: Conyza sp. | Homo sapiens | Mus musculus | Protein complex | Triticum sp. | Beckmann, R. | Gartmann, M. | Halic, M. | Mielke, T. | Pool, M.R. | Schlenker, O. | Sinning, I. | Ribosome | Sr | Srp
