2h32

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Image:2h32.jpg

2h32, resolution 2.70Å

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Crystal structure of the pre-B cell receptor

Overview

The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell, development. In the 2.7 angstrom structure of a human pre-BCR Fab-like, fragment, consisting of an antibody heavy chain (HC) paired with the, surrogate light chain, the "unique regions" of VpreB and lambda5 replace, the complementarity-determining region 3 (CDR3) loop of an antibody light, chain and appear to "probe" the HC CDR3, potentially influencing the, selection of the antibody repertoire. Biochemical analysis indicates that, the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling, mechanism.

About this Structure

2H32 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:17431183

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