2lyh

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Template:STRUCTURE 2lyh

Structure of Faap24 residues 141-215

Function

[FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

About this Structure

2lyh is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

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