2hdc

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Image:2hdc.gif

2hdc

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STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

Overview

Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR, techniques, we have obtained the solution structure and backbone dynamics, of Genesis complexed with a 17 base-pair DNA. Our results indicate that, both the local folding and dynamic properties of Genesis are perturbed, when it binds to the DNA site. Our data show that a conserved flexible, amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex, and a short helix is induced by Genesis-DNA interactions. Our data, indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not, required in forming the stable Genesis-DNA complex.

About this Structure

2HDC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754

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