2if4

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Image:2if4.gif

2if4, resolution 2.85Å

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Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana

Overview

FKBP42 is a membrane-anchored immunophilin playing a critical role in, morphogenesis and development of higher plants. We present the X-ray, structure of the cytoplasmic portion of FKBP42 comprising both the, FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed, light on the probable binding modes of key interaction partners, including, HSP90 and two classes of ABC transporters. The resulting models provide a, structural background for further investigation of the unique biological, properties of this protein.

About this Structure

2IF4 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: a paradigm for regulation of plant ABC transporters., Granzin J, Eckhoff A, Weiergraber OH, J Mol Biol. 2006 Dec 8;364(4):799-809. Epub 2006 Sep 26. PMID:17045295

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