Catechol O-methyltransferase (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.
3D Structures of catechol O-methyltransferase
Updated on 25-June-2013
2zlb – rCOMT – rat
2zth – rCOMT + SAM
3u81 – rCOMT (mutant) + SAH
2vid – rCOMT + SAM + dinitrocatechol
1jr4, 3hvh, 3hvi, 3hvj, 3hvk, 3a7d, 3nw9, 3nwb, 3nwe – rCOMT + inhibitor
3oe4, 3oe5, 3ozr, 3ozs, 3ozt, 3r6t – rCOMT (mutant) + inhibitor
1h1d, 2cl5, 2zvj, 3s68 – rCOMT + inhibitor + SAM
3bwm, 3a7e – hCOMT + SAM + dinitrocatechol – human
3bwy – hCOMT (mutant) + SAM + dinitrocatechol
