TATA-Binding Protein
From Proteopedia
TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, i.e. the crystal structure of yeast TATA-binding protein (1tbp). See also Transcription and RNA Processing.
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3D Structures of TATA-binding protein
Updated December 2011
TBP
2z8u – TBP – Methanococcus janaschii
1pcz – PwTBP - Pyrococcus woesei
1vok – AtTBP - Arabidopsis thaliana
1tbp – yTBP - yeast
1mp9 – TBP – Sulfolobus acidocaldarius
3eik – TBP – Encephalitozoon cuniculi
TBP+DNA TATA
1ytb - yTBP + DNA TATA
1cdw - hTBP core domain+ DNA TATA - human
1tgh - hTBP + DNA TATA
1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4, 1vto - AtTBP + DNA TATA
TBP+DNA TATA+TFIIA
1rm1 – yTBP+TFIIA α, β, γ chains+ DNA TATA
1ytf - yTBP+TFIIA + DNA TATA
1nh2 – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA
1nvp - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA
1jfi - hTBP C-terminal+ TFIIA NC2+ DNA TATA
TBP+DNA TATA+TFIIB
1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR
1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter
1vol – AtTBP+hTFIIB+DNA TATA
1ais, 1d3u - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR
Additional information
See: Transcription for additional Proteopedia resources
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called the to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif
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Proteopedia Page Contributors and Editors (what is this?)
Ala Jelani, Michal Harel, Eran Hodis, Alexander Berchansky, David Canner
